ubl
The Effect of Serum BDNF Levels on Central Serotonin Transporter Availability in Obese Versus Non-Obese Adults: A [11C]DASB Positron Emission Tomography Study
2016-11-29
[Electronic ed.]
prv
Universitätsbibliothek Leipzig
Universitätsbibliothek Leipzig, Leipzig
Klinik und Poliklinik für Nuklearmedizin
male
Bad Säckingen
Background: Serotonin (5-HT) and its neurotrophic support system, specifically brain-derived neurotrophic factor (BDNF), are thought to modulate energy homeostasis and susceptibility to obesity. Moreover, a polymorphism (5-HTTLPR) in the serotonin reuptake transporter (5-HTT) gene impairs its transcription, thereby altering serotonergic tone and potentially contributing to such susceptibility. This study aims to investigate the effect of BDNF, biallelic 5-HTTLPR, and central in-vivo 5-HTT availability in highly obese versus non-obese subjects using positron emission tomography (PET) and 5-HTT selective [11C]DASB.
Methods: Thirty-eight subjects, 24 obese (body mass index, BMI, >35 kg/m2), otherwise mentally and physically healthy, and 14 non-obese (BMI ≤ 25 kg/m2), age- and sex-matched healthy controls were included in this study. Parametric images of binding potential were generated from PET data. Central 5-HTT availability, 5-HTTLPR genotype, and serum BDNF concentrations were analyzed, first in a volume of interest, then in a voxel-wise manner.
Results: Overall, our results showed an absence of a linear correlation between BDNF, in-vivo central 5-HTT availability, and body mass index (BMI). 5-HTTLPR genotyping revealed BDNF and hippocampal 5-HTT availability to be negatively correlated (r = −0.57, p = 0.007) in long allelic homozygotes. However, obese subjects exhibited opposing effects of BDNF levels on 5-HTT availability in the nucleus accumbens (NAcc) relative to our non-obese controls.
Conclusions: Our data did not confirm an overall correlation between serum BDNF, in-vivo central 5-HTT availability, 5-HTTLPR, and BMI. However, there is evidence that serotonergic tone linked to BDNF, specifically in the NAcc, is involved in the pathophysiology of obesity, although this needs further exploration over a wide range of reward-related eating behaviors.
610
SERT, BDNF, PET, Adipositas
SERT, BDNF, PET, obesity
urn:nbn:de:bsz:15-qucosa-214753
Universität Leipzig
dgg
Universität Leipzig, Leipzig
Philipp
Hinderberger
1985-09-08
aut
Swen
Hesse
Prof. Dr.
dgs
Axel
Rominger
Prof. Dr.
rev
Anja
Hilbert
Prof. Dr.
rev
eng
2016-05-10
2016-11-08
born digital
Philipp Hinderberger
phinder@gwu.edu
doctoral_thesis